stains | Pathology Student

Reticulin vs. collagen fibrosis

Q. Â What is the difference between reticulin fibrosis and collagen fibrosis (the two terms used in the WHO criteria for grading myelofibrosis)? (more…)

Can you solve this case?

Here’s another unknown case in our small-but-growing collection (you can find other cases here, here, here andÂ here). (more…)

Undifferentiated tumors: solving the mystery

Q. When a squamous cell carcinoma is designated as “poorly differentiated”, what other parameters/tests are performed to determine the tissue of origin?

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Glucose 6 phosphate dehydrogenase deficiency

Next in our little series on hereditary hemolytic anemias is glucose 6 phosphate dehydrogenase (or G6PD) deficiency. (more…)

Leukocyte alkaline phosphatase

What if you had a blood smear in which you thought the diagnosis was chronic myeloid leukemia (CML), but you didn’t have access to a cytogenetic or molecular lab (to look for the Philadelphia chromosome or the bcr-abl translocation)? (more…)