Here’s one of those things in pathology that will lead you to pull all your hair out: what is the difference between nephrotic and nephritic syndrome?
Ugh. They both involve the kidney, they both are syndromes so they’re probably both constellations of findings, and the names are maddeningly similar except for one stinking vowel. How can a person be expected to memorize these things?
Let’s start with the main features of each syndrome. We’ll pick four features for each, since it’s really hard to remember more than four of anything.
1. Massive proteinuria
How do you make these lists hang together in a way that you can remember?
First, let’s take nephrotic syndrome. The thing to remember for this one is massive proteinuria. You might do this by remembering that nephrotic and protein both have an “o” in them. The massive proteinuria in these patients leads to hypoalbuminemia (they are peeing out albumin!), which results in edema (the oncotic pressure in the blood goes down, and fluid leaks out of the vasculature into the surrounding tissue). So right there, you have three of the four features, just by remembering one. The cause of the last feature, hyperlipidemia/hyperlipiduria, is less well-understood, so you’re just going to have to memorize that one. As an aside, nephrotic syndrome is often more dangerous than nephritic syndrome, so you might want to think of this syndrome as the “oh sh*t” syndrome (again – nephrotic has an o in it, nephritic does not). Crude, but if it works, who cares?
In nephritic syndrome, there is some proteinuria and edema, but it’s not nearly as severe as in nephrotic syndrome. The thing with nephritic syndrome is that the lesions causing it all have increased cellularity within the glomeruli, accompanied by a leukocytic infiltrate (hence the suffix -itic). The inflammation injures capillary walls, permitting escape of red cells into urine. Hemodynamic changes cause a decreased glomerular filtration rate (manifested clinically as oliguria and azotemia). The hypertension seen in nephritic syndrome is probably a result of fluid retention and increased renin released from ischemic kidneys.
If you really want to pare it down – if you only have enough brain space to remember one feature for each disorder – remember that nephrotic syndrome is characterized by massive proteinuria (the “o” in nephrotic), and nephritic syndrome is characterized by inflammation (the “-itic” in nephritic). Then at least you’ll have a shot at remembering the other features.
Note: The image above is of Streeter Seidell, a comedian, and was taken by Zach Klein. It can be found at http://www.flickr.com/photos/zachklein/54389823/.
- Elaine Puricelli said Hello, Thanks for the info on Howell Jolly bodies. I have had these critters consistently since my s...
- Sarkaft said دست خووش… Thsnks alot
- shiru said thankyou thankyou… im surely going to pass my finals. pathology student rocks my world!!!!!!!!
- rajesh said best explanation we can ever get. thank u so much
- Jason said Amazing resource. This and the article on phemphigous vulgerus and bullous phemphigoid difference ar...
- Amanulla said Do people with O blood group also have H antigen?
- vivek said Thanks for sharing
- Raffi said Thank you for your detailed response!
- Kristine said WOW, Luisa, that’s GREAT!!! So happy for you! I would say “had” at this point
- Kristine said Thanks, Venessa Yeah, I know what you mean…sometimes teaching is seen more as an unpleasant t...
- Kristine said Haha that’s hilarious!! I love that
- Kristine said Good question! The little bit of thrombin that has been formed by the extrinsic pathway is the the t...