It would be cool if there was some medication that could lengthen one’s lifespan (while at the same time, keeping the skin plump and rosy)...something like Ponce de Leon’s fountain of youth, maybe spiked with a little telomerase. According to Robbins, however, studies have shown that the most effective way to prolong life is to seriously restrict one’s calorie intake. How boring.
Apparently, the effect of calorie restriction on longevity is mediated by a bunch of proteins called sirtuins. These proteins have histone deacetylase activity, and they stimulate the production of life-lengthening gene products that do things like:
- increase metabolic activity
- reduce apoptosis
- stimulate protein folding
- decrease free-radical damage
Sirtuins also increase insulin sensitivity and glucose metabolism…so they’re being looked at as targets for diabetes treatment. That all sounds great.
However, it also seems that sirtuins may be linked to anxiety. Higher levels of sirtuins seem to make mice more anxious, and some humans with anxiety disorders have been shown to have higher levels of sirtuins (as nicely summarized in this MIT study). The researchers at MIT say that anxiety during periods of low food availability might be an an evolutionary adaption (if you have to forage widely for food, a little extra wariness and caution could save your life).
Hmmm…a long, hungry, anxious life vs. a short, full, happy life. I’ll have to think about that one.
Tagsacute leukemia acute lymphoblastic leukemia acute myeloid leukemia acute promyelocytic leukemia Add new tag anemia b cells blood smear bone marrow brain tumors carcinoma cases chronic myelofibrosis chronic myeloid leukemia chronic myeloproliferative disorders coagulation cortisol cytochemistry cytogenetics essential thrombocythemia heart hemophilia immunology infection inflammation kaplan kidney laboratory tests lymphocyte lymphocytes lymphoma macrophages neoplasia neutrophil normal photoblog polycythemia vera red blood cells red cells sickle cell anemia skin squamous cell carcinoma stains student questions t cells
- Kristine said Oh. Good question. Sometimes the word “pseudopalisading” is used when there is necrosis...
- Ujwal said What do we meant by pseudopalisading? I got confused by above answer of palisading with example of n...
- Doaa said Great learning site. I hope that you strongly focus on macro and micro photos for illustration. Than...
- Ujwal said Thank You so much for the informations. Really glad.
- Liz said Great site & even more excited to see that you’re local!
- Leandro Zuniga said Nices and helpful explanation, thanks a lot.
- Kristine said Good question! Polarity refers to the orientation of cells. For example, epithelial cells in glands...
- m.hamdy said thanks very much, i want to know the difference between polarity and palisading
- mark dorotic said Microphotographs are excellent, very sharp and real color, the description text is very precise and...
- mark dorotic said Excellent explanation!
- Lyn said Wow! Good thing I found this! Really helped me a lot! Thanks
- Muhammad Murad said oh, you made my life easy. Thank you