It would be cool if there was some medication that could lengthen one’s lifespan (while at the same time, keeping the skin plump and rosy)...something like Ponce de Leon’s fountain of youth, maybe spiked with a little telomerase. According to Robbins, however, studies have shown that the most effective way to prolong life is to seriously restrict one’s calorie intake. How boring.
Apparently, the effect of calorie restriction on longevity is mediated by a bunch of proteins called sirtuins. These proteins have histone deacetylase activity, and they stimulate the production of life-lengthening gene products that do things like:
- increase metabolic activity
- reduce apoptosis
- stimulate protein folding
- decrease free-radical damage
Sirtuins also increase insulin sensitivity and glucose metabolism…so they’re being looked at as targets for diabetes treatment. That all sounds great.
However, it also seems that sirtuins may be linked to anxiety. Higher levels of sirtuins seem to make mice more anxious, and some humans with anxiety disorders have been shown to have higher levels of sirtuins (as nicely summarized in this MIT study). The researchers at MIT say that anxiety during periods of low food availability might be an an evolutionary adaption (if you have to forage widely for food, a little extra wariness and caution could save your life).
Hmmm…a long, hungry, anxious life vs. a short, full, happy life. I’ll have to think about that one.
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- Janarthan Rama Murti said WOW!!!!!!!!!!!! THIS IS SO COOL Awesome answer Dr Kris…Thanks for eN-Riching our knowledge on...
- Kristine said Thanks, Edwin! So glad you found some useful stuff here! Thanks for all the nice compliments Sound...
- Janarthan Rama Murti said Thank you so much Dr Kristine!!!!!!!!!!!!!!!!
- Janarthan Rama Murti said AWESOME!!!!!!!!!!!!!!!!!!!!!!!!
- Edwin Halim said This truly is one-of-a-kind site!! Amzazingly done, Kristine.. If i may add, it would be truly aweso...
- Janarthan Rama Murti said Great explanation… As a corollary, does this mean INR/PT test for Extrinsic Pathway (EP), In...
- Vijay said Very informative
- Kristine said Thanks for your comments! This is an older case that was previously diagnosed as bronchioloalveolar...
- Kirk Jones said The findings in your picture actually look more consistent with papillary or micropapillary pattern...
- Kristi said Got PV at the tail end of 2011, had thrush and couldn’t even swallow water, hair loss, had to...
- Dr Khandke said Best explained
- Salihu Ahmad yoffo said Very interested page