A 38 year-old male with advanced AIDS presents with severe headaches, fever and altered mental status, and dies several days later. An autopsy is performed, and a coronal section of the brain is shown here.
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A 59 year-old male presents with severe headaches and fatigue of several months’ duration. A 4 cm, poorly-defined, necrotic left cerebral mass is found on CT and is subsequently biopsied.
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A 72 year-old male presents with an ill-defined, deep-seated mass in his right calf. It has grown appreciably in the past few months and is now roughly the size of a golf ball. A core biopsy is performed, and a representative section is shown here.
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Here’s a little quiz on female reproductive (and breast) pathology. Answers and explanations are posted at the bottom. (more…)

Q. I’m now studying for USMLE and have something which is really confusing, I’m hoping you might be able to help! I see the term “Owl’s eye” thrown around for both Reed Sternberg cells of Hodgkin’s Lymphoma as well as for CMV. (more…)

Q. How do you identify mitoses in histology slides?
A. Great question. This is something pathologists have to do a lot and nobody really talks about what specifically makes a mitotic figure.
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Desmoid tumor, also called deep-seated fibromatosis, is a benign tumor that is nonetheless a nasty beast. (more…)

Myelodysplasia (MDS) is often thought of as “pre-leukemia.” Which is kind of misleading, because only some cases of MDS go on to become leukemia; others stay the same and never progress. (more…)

Rosettes are little round groupings of cells found in tumors. They usually consist of cells in a spoke-wheel or halo arrangement surrounding a central, acellular region. (more…)

I’m happy to announce the newest member of our growing family of study guides: the General Pathology Compendium. (more…)
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