A 72 year-old male with a deep calf mass

A 72 year-old male presents with an ill-defined, deep-seated mass in his right calf. It has grown appreciably in the past few months and is now roughly the size of a golf ball. A core biopsy is performed, and a representative section is shown here.
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Owl’s eye nuclei

Q. I’m now studying for USMLE and have something which is really confusing, I’m hoping you might be able to help! I see the term “Owl’s eye” thrown around for both Reed Sternberg cells of Hodgkin’s Lymphoma as well as for CMV. (more…)

How do you identify mitoses?

Q. How do you identify mitoses in histology slides?

A. Great question. This is something pathologists have to do a lot and nobody really talks about what specifically makes a mitotic figure.

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Myelodysplasia: not quite leukemia



Myelodysplasia (MDS) is often thought of as “pre-leukemia.” Which is kind of misleading, because only some cases of MDS go on to become leukemia; others stay the same and never progress. (more…)