Schistocytes, spherocytes, and bite cells
Q. What is the difference between schistocytes, spherocytes, and bite cells?
A. Schistocytes are fragmented red cells. You see them in microangiopathic hemolytic anemia. (more…)
Megaloblastic anemia and macrocytosis
Q. I’m confused how in megablastic anemia, cells become macrocytic due to immature nuclei when RBCs don’t have nuclei! Is it referring to the erythroblast precursors before the nuclei are lost?
What makes the juxtaglomerular apparatus release renin?
Q. What triggers renin release? I know that it’s hypo-filtration of the juxtaglomerular apparatus (i.e. reduced fluid flow) but what is the actual trigger for renin release? (more…)
What’s the deal with ADAMTS 13?
Q. We learnt about a pretty rare disorder called thrombotic thrombocytopenic purpura (TTP) in which super-huge von Willebrand Factor (vWF) multimers are made which lead to occlusion of microcirculation. (more…)
Where does von Willebrand Factor come from?
Q. I have a question about von Willebrand Factor – where is it stored? All that I can gather is that it’s stored in ‘Weibel-Palade bodies’, but where are they? (more…)
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