Papillary thyroid carcinoma has a number of unique morphologic features. I mentioned psammoma bodies a few days ago. Illustrated above is another characteristic feature: Orphan Annie nuclei. These are so named because they have a “cleared-out” appearance, similar to Little Orphan Annie’s eyes. In fact, you can think of papillary thyroid carcinoma as the Little Orphan Annie tumor because:
1. It stays around for years and years without getting any bigger (papillary carcinoma is slow growing).
2. It is well-behaved and seldom kills people (overall, the 10-year survival for papillary carcinoma is >90%, which is better than the prognosis of any of the other types of thyroid carcinoma).
3. The nuclei resemble Little Orphan Annie’s eyes.
4. It often has psammoma bodies (derived from the Greek psammos, or sand): Annie’s dog is named Sandy.
I wish I could say I came up with this, but it comes from Ed’s Pathology Notes, a really wonderful pathology site for students (and anyone interested in pathology) at www.pathguy.com.
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- Kristine said Looks like a naked nucleus to me – and a damaged one, at that. I don’t see any real cyto...
- Christine said What is the large teardrop shaped cell at 2:00? And how did it get that way?
- Kristine said Yes! Exactly! All non-antigen-presenting cells have 6 different types of class II MHC (HLA) molecule...
- daryan said A really helpful and clear explanation. Thank you!
- AMINATU ADAMU said thank u so much for helping me
- Nargis said Thanks a lot.. I am glad that I came across this site of yours
- dr muhammad haroon said Great explanation! Very informative and actually makes sense. Thank you!
- SIMI SADASIVAN said excellent!you teach it as a simple language.more helpful to us.Thank u
- Kristine said So glad you liked it! Thank you!
- Chikaodiri said Wow so simplistic. Thank you Dr. Kristine.
- MMM said Oh boy, I’m so confused with this and your explanation is great! Just now more question: so 6...
- Papa Bear said Thank you so much for clarifying! I really appreciate it!