Reticulin vs. collagen fibrosis
Q. What is the difference between reticulin fibrosis and collagen fibrosis (the two terms used in the WHO criteria for grading myelofibrosis)? (more…)
A 45 year-old male with emphysema and hepatitis
A 45 year-old male presents with pulmonary emphysema and repeated bouts of hepatitis. On liver biopsy, there are numerous eosinophilic, globular inclusions, such as the one at the center of the field.
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Undifferentiated tumors: solving the mystery
Q. When a squamous cell carcinoma is designated as “poorly differentiated”, what other parameters/tests are performed to determine the tissue of origin?
Glucose 6 phosphate dehydrogenase deficiency
Next in our little series on hereditary hemolytic anemias is glucose 6 phosphate dehydrogenase (or G6PD) deficiency. (more…)
Leukocyte alkaline phosphatase
What if you had a blood smear in which you thought the diagnosis was chronic myeloid leukemia (CML), but you didn’t have access to a cytogenetic or molecular lab (to look for the Philadelphia chromosome or the bcr-abl translocation)? (more…)
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