Cytogenetics quiz
Many hematopoietic malignancies have characteristic cytogenetic changes, such as translocations or inversions. It’s important to know about these because they can be used for diagnosis in tough cases, and they often carry a prognostic significance. Here’s a little quiz to refresh your memory. See if you can name the hematologic malignancy associated with each of these cytogenetic changes. Answers are in the first comment associated with this post.
1. t(9;22)
2. t(8;21)
3. t(8;14)
4. Flt-3 mutation
5. t(15;17)
6. translocation involving 11q23
7. inv(16)
8. t(14;18)
9. t(11;14)
10. Jak-2 mutation
Note: the cool photo of chromosomes was taken by slushpup and can be found at: http://www.flickr.com/photos/slushpup/152994192/in/set-72157594144061014/.
